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Article

Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections.

Journal of virology - 1 Jan 2011

Mun Ho-Suk, Lee Seoung-Ae, Kim Hong, Hwang Eung-Soo, Kook Yoon-Hoh, Kim Bum-Joon

Abstract excerpt

Several lines of evidence have suggested that some naturally occurring mutations of hepatitis B virus (HBV) play a critical role in hepatocellular carcinoma (HCC). Here, we describe a novel HCC-related pre-S2 mutation, F141L. To prove the relationship between the F141L mutation and HCC, molecular epidemiology studies using MboII PCR restriction analysis (PRA) were performed, and the molecular mechanism was...

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Topics

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Share to Carcinoma, Hepatocellular
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B Surface Antigens

Share to Hepatitis B virus

Share to Hepatocytes

Share to Liver Neoplasms

Share to Protein Precursors

Source

Open in PubMed Open full text

Identifiers

PMID: 20962085
DOI: 10.1128/JVI.01524-10
PMCID: PMC3014212

Genes

LHB
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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