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Article

Functional communications between the apical and equatorial domains of GroEL through the intermediate domain.

Biochemistry - 30 Nov 1999

Kawata Y, Kawagoe M, Hongo K, Miyazaki T, Higurashi T, Mizobata T, Nagai J

Abstract excerpt

The Escherichia coli GroEL subunit consists of three domains with distinct functional roles. To understand the role of each of the three domains, the effects of mutating a single residue in each domain (Y203C at the apical, T89W at the equatorial, and C138W at the intermediate domain) were studied in detail, using three different enzymes (enolase, lactate dehydrogenase, and rhodanese) as refolding substrates. By...

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Identifiers

PMID: 10625439
DOI: 10.1021/bi9909750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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