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Article

Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis.

Frontiers in bioscience (Landmark edition) - 1 Jan 2011

Wells Alan, Chao Yvonne L, Grahovac Jelena, Wu Qian, Lauffenburger Douglas A

Abstract excerpt

The most ominous stage of cancer progression is metastasis, or the dissemination of carcinoma cells from the primary site into distant organs. Metastases are often resistant to current extirpative therapies and even the newest biological agents cure only a small subset of patients. Therefore a greater understanding of tumor biology that integrates properties intrinsic to carcinomas with tissue environmental...

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Identifiers

PMID: 21196205
DOI: 10.2741/3722
PMCID: PMC4003907

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