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Article

UGT1A11/28 and 1/6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer.

Cancer chemotherapy and pharmacology - 1 Aug 2011

Sunakawa Yu, Ichikawa Wataru, Fujita Ken-Ichi, Nagashima Fumio, Ishida Hiroo, Yamashita Keishi, Mizuno Keiko, Miwa Keisuke, Kawara Kaori, Akiyama Yuko, Araki Kazuhiro, Yamamoto Wataru, Miya Toshimichi, Narabayashi Masaru, Ando Yuichi, Hirose Takashi, Saji Shigehira, Sasaki Yasutsuna

Abstract excerpt

PURPOSE: Differences in efficacy and toxicity between UDP-glucuronosyltransferase (UGT) 1A1*1/*1 and *1/*6 or *1/*28 genotypes remain unclear in Japanese patients. METHODS: Patients with advanced colorectal cancer who received irinotecan combined with 5-fluorouracil plus l-leucovorin (FOLFIRI) as first-line therapy were divided into two groups: those with UGT1A1*1/*1 genotype and those with UGT1A1*1/*6 or *1/*28...

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PMID: 20957480
DOI: 10.1007/s00280-010-1485-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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