Article
Regimen selection for first-line FOLFIRI and FOLFOX based on UGT1A1 genotype and physical background is feasible in Japanese patients with advanced colorectal cancer.
Japanese journal of clinical oncology - 1 May 2011
Ishida Hiroo, Fujita Ken-Ichi, Akiyama Yuko, Sunakawa Yu, Yamashita Keishi, Mizuno Keiko, Miwa Keisuke, Kawara Kaori, Ichikawa Wataru, Ando Yuichi, Saji Shigehira, Sasaki Yasutsuna
Abstract excerpt
OBJECTIVE: We examined the feasibility of regimen selection for first-line irinotecan, 5-fluorouracil and leucovorin or oxaliplatin, 5-fluorouracil and leucovorin in Japanese patients with advanced colorectal cancer based on UDP-glucuronosyltransferase 1A1 genotype as well as physical status of patients related to diarrhea. METHODS: As first-line irinotecan, 5-fluorouracil and leucovorin is a little bit superior...
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