UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan.

doi:10.1111/cas.12283

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Article

UGT1A16, 1A73, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan.

Cancer science - 1 Dec 2013

Hazama Shoichi, Mishima Hideyuki, Tsunedomi Ryouichi, Okuyama Yusuke, Kato Takeshi, Takahashi Ken-ichi, Nozawa Hiroshi, Ando Hideaki, Kobayashi Michiya, Takemoto Hiroyoshi, Nagata Naoki, Kanekiyo Shinsuke, Inoue Yuka, Hamamoto Yoshihiko, Fujita Yusuke, Hinoda Yuji, Okayama Naoko, Oba Koji, Sakamoto Jun-ichi, Oka Masaaki

Abstract excerpt

UNLABELLED: Retrospective studies have suggested that UDP-glucuronosyltransferase (UGT)1A1, UGT1A7, and UGT1A9 predict severe toxicity and efficacy of irinotecan-containing regimens. We prospectively evaluated the impact of UGT1A genotypes and haplotypes on severe toxicity and efficacy in patients treated with fluorouracil, leucovorin, and irinotecan combination chemotherapy (FOLFIRI) for metastatic colorectal...

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PMID: 24033692
DOI: 10.1111/cas.12283
PMCID: PMC7653527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan.PMID 24033692Read ↗

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Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.Semantic proximity Read ↗

UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer.Semantic proximity Read ↗

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Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer：a study from Guangxi ZhuangSemantic proximity Read ↗

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UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan.Semantic proximity Read ↗

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