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Article

Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010

Xu Xingshun, Yang Hao, Lin Yung-Feng, Li Xiang, Cape Austin, Ressler Kerry J, Li Shihua, Li Xiao-Jiang

Abstract excerpt

Recent studies suggest that the human Abelson helper integration site-1 (AHI1) gene on chromosome 6 is associated with susceptibility to schizophrenia and autism, two common neuropsychological disorders with depression symptoms. Mouse Ahi1 protein is abundant in the hypothalamus and amygdala, whi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20956301
DOI: 10.1073/pnas.1013032107
PMCID: PMC2973903

Genes

AHI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20956301-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.PMID 20956301Read ↗

Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in miceSemantic proximity Read ↗

Lymphoblast and brain expression of AHI1 and the novel primate-specific gene, C6orf217, in schizophrenia and bipolar disorder.Semantic proximity Read ↗

A cis-eQTL in AHI1 confers risk to schizophrenia in European populations.Semantic proximity Read ↗

The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome.Semantic proximity Read ↗

Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.Semantic proximity Read ↗

Fine mapping of AHI1 as a schizophrenia susceptibility gene: from association to evolutionary evidence.Semantic proximity Read ↗

ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.Semantic proximity Read ↗

A mouse model of ATRX deficiency with cognitive deficits and autistic traitsSemantic proximity Read ↗

Abelson Helper Integration Site-1 Gene Variants on Major Depressive Disorder and Bipolar DisorderSemantic proximity Read ↗

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Identification of activity-induced <i>Egr3</i> -dependent genes reveals genes associated with DNA damage response and schizophreniaSemantic proximity Read ↗

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