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Article

The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome.

Metabolism: clinical and experimental - 1 Jul 2010

Prior Matthew J, Foletta Victoria C, Jowett Jeremy B, Segal David H, Carless Melanie A, Curran Joanne E, Dyer Tom D, Moses Eric K, McAinch Andrew J, Konstantopoulos Nicky, Bozaoglu Kiymet, Collier Greg R, Cameron-Smith David, Blangero John, Walder Ken R

Abstract excerpt

The human Abelson helper integration site-1 (AHI1) gene is associated with both neurologic and hematologic disorders; however, it is also located in a chromosomal region linked to metabolic syndrome phenotypes and was identified as a type 2 diabetes mellitus susceptibility gene from a genomewide...

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Source

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Identifiers

PMID: 20045148
DOI: 10.1016/j.metabol.2009.11.002
PMCID: PMC3249385

Genes

AHI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20045148-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome.PMID 20045148Read ↗

Abelson Helper Integration Site-1 Gene Variants on Major Depressive Disorder and Bipolar DisorderSemantic proximity Read ↗

Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.Semantic proximity Read ↗

Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.Semantic proximity Read ↗

Association of copy number variation in the AHI1 gene with risk of obesity in the Chinese population.Semantic proximity Read ↗

Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome.Semantic proximity Read ↗

A cis-eQTL in AHI1 confers risk to schizophrenia in European populations.Semantic proximity Read ↗

An antisense Alu transposon insertion/deletion polymorphism of ALDH1A1 may functionally associate with Parkinson's disease.Semantic proximity Read ↗

Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in miceSemantic proximity Read ↗

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish.Semantic proximity Read ↗

Lymphoblast and brain expression of AHI1 and the novel primate-specific gene, C6orf217, in schizophrenia and bipolar disorder.Semantic proximity Read ↗

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.Semantic proximity Read ↗

Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation.Semantic proximity Read ↗

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