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Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population.

Atherosclerosis - 1 May 2015

Han Yi, Dorajoo Rajkumar, Ke Tingjing, Ayala Burger, Chang Xuling, Khor Chiea-Chuen, van Dam Rob M, Yuan Jian-Min, Koh Woon-Puay, Liu Jianjun, Goh Daniel Y T, Friedlander Yechiel, Heng Chew-Kiat

Abstract excerpt

OBJECTIVE: Paraoxonase 1 (PON1) plays an important role in reducing the risk of coronary heart disease (CHD). Smoking is known to reduce PON1 activity. We aimed to investigate the effects of interactions between PON1 variants and smoking on CHD in the Singaporean Chinese population. METHODS: In a case-control study nested within Singapore Chinese Health Study (N=1914), subjects with and without CHD were...

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Identifiers

PMID: 25746376
DOI: 10.1016/j.atherosclerosis.2015.01.042
PMCID: PMC4501379

Genes

PON1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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