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Article

Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors.

International journal of radiation oncology, biology, physics - 1 Feb 2011

Singh Satyendra K, Wu Wenqi, Zhang Lihua, Klammer Holger, Wang Minli, Iliakis George

Abstract excerpt

PURPOSE: The backup pathway of nonhomologous end joining (B-NHEJ) enables cells to process DNA double-strand breaks (DSBs) when the DNA-PK-dependent pathway of NHEJ (D-NHEJ) is compromised. Our previous results show marked reduction in the activity of B-NHEJ when LIG4(-/-) mouse embryo fibroblasts (MEFs) cease to grow and enter a plateau phase. The dependence of B-NHEJ on growth state is substantially stronger...

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Source

Identifiers

PMID: 20950945
DOI: 10.1016/j.ijrobp.2010.08.018

Genes

LIG4
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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