Article
A functional genetic link between distinct developmental language disorders.
The New England journal of medicine - 27 Nov 2008
Vernes Sonja C, Newbury Dianne F, Abrahams Brett S, Winchester Laura, Nicod Jérôme, Groszer Matthias, Alarcón Maricela, Oliver Peter L, Davies Kay E, Geschwind Daniel H, Monaco Anthony P, Fisher Simon E
Abstract excerpt
BACKGROUND: Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment. METHODS: We performed genomic screening for regions bound by FOXP2 using chromatin immunoprecipitation, which led us to focus on one particular gene that was a strong...
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