Article
FOXP1 mutations cause intellectual disability and a recognizable phenotype.
American journal of medical genetics. Part A - 1 Dec 2013
Le Fevre Anna K, Taylor Sharelle, Malek Neva H, Horn Denise, Carr Christopher W, Abdul-Rahman Omar A, O'Donnell Sherindan, Burgess Trent, Shaw Marie, Gecz Jozef, Bain Nicole, Fagan Kerry, Hunter Matthew F
Abstract excerpt
Mutations in FOXP1, located at 3p13, have been reported in patients with global developmental delay (GDD), intellectual disability (ID), and speech defects. Mutations in FOXP2, located at 7q31, are well known to cause developmental speech and language disorders, particularly developmental verbal dyspraxia (DVD). FOXP2 has been shown to work co-operatively with FOXP1 in mouse development. An overlap in FOXP1 and...
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