Article
MET mutations in cancers of unknown primary origin (CUPs).
Human mutation - 1 Jan 2011
Stella Giulia M, Benvenuti Silvia, Gramaglia Daniela, Scarpa Aldo, Tomezzoli Anna, Cassoni Paola, Senetta Rebecca, Venesio Tiziana, Pozzi Ernesto, Bardelli Alberto, Comoglio Paolo M
Abstract excerpt
Cancer of unknown primary origin (CUP) defines metastatic disease of unknown origin, accounting for 3-5% of all cancers. Growing evidence demonstrates that inappropriate execution of a genetic program named "invasive growth," driven by the MET oncogene, is implicated in the metastatic process. MET activation in cancers is mainly consequent to overexpression, whereas mutations are rarely found. We reasoned that...
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