Article
Emergence of insulin resistance in juvenile baboon offspring of mothers exposed to moderate maternal nutrient reduction.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2011
Choi Jaehyek, Li Cun, McDonald Thomas J, Comuzzie Anthony, Mattern Vicki, Nathanielsz Peter W
Abstract excerpt
Developmental programming of postnatal pancreatic β-cell and peripheral insulin function by maternal nutrient reduction (MNR) has been extensively investigated in rodents and sheep, but no data exist from nonhuman primate offspring of MNR mothers. We hypothesized that moderate levels of MNR would result in developmental programming of postnatal β-cell function and peripheral insulin sensitivity that lead to...
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