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Article

The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication.

Journal of virology - 1 Dec 2010

Cao Dianjun, Huang Yao-Wei, Meng Xiang-Jin

Abstract excerpt

The roles of conserved nucleotides on the stem-loop (SL) structure in the intergenic region of the hepatitis E virus (HEV) genome in virus replication were determined by using Huh7 cells transfected with HEV SL mutant replicons containing reporter genes. One or two nucleotide mutations of the AGA motif on the loop significantly reduced HEV replication, and three or more nucleotide mutations on the loop abolished...

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Identifiers

PMID: 20943962
DOI: 10.1128/JVI.01475-10
PMCID: PMC3004356

Genes

AGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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