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Article

In vitro and in vivo mutational analysis of the 3'-terminal regions of hepatitis e virus genomes and replicons.

Journal of virology - 1 Jan 2005

Graff Judith, Nguyen Hanh, Kasorndorkbua Chaiyan, Halbur Patrick G, St Claire Marisa, Purcell Robert H, Emerson Suzanne U

Abstract excerpt

Hepatitis E virus (HEV) replication is not well understood, mainly because the virus does not infect cultured cells efficiently. However, Huh-7 cells transfected with full-length genomes produce open reading frame 2 protein, indicative of genome replication (6). To investigate the role of 3'-terminal sequences in RNA replication, we constructed chimeric full-length genomes with divergent 3'-terminal sequences of...

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Identifiers

PMID: 15613330
DOI: 10.1128/JVI.79.2.1017-1026.2005
PMCID: PMC538530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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