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Article

Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2011

Lazary Judit, Juhasz Gabriella, Anderson Ian M, Jacob Christian P, Nguyen T Trang, Lesch Klaus-Peter, Reif Andreas, Deakin J F William, Bagdy Gyorgy

Abstract excerpt

G protein-activated K+ channel 2 (GIRK2) and cAMP-response element binding protein (CREB1) are involved in synaptic plasticity and their genes have been implicated depression and memory processing. Excessive rumination is a core cognitive feature of depression which is also present in remission. High scores on the Ruminative Response Scale (RRS) questionnaire are predictive of relapse and recurrence. Since...

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Source

Identifiers

PMID: 20943350
DOI: 10.1016/j.euroneuro.2010.09.009

Genes

KCNJ6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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