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Article

Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression.

Translational psychiatry - 1 Mar 2016

Eszlari N, Kovacs D, Petschner P, Pap D, Gonda X, Elliott R, Anderson I M, Deakin J F W, Bagdy G, Juhasz G

Abstract excerpt

Alterations in the folate pathway have been related to both major depression and cognitive inflexibility; however, they have not been investigated in the genetic background of ruminative response style, which is a form of perseverative cognition and a risk factor for depression. In the present study, we explored the association of rumination (measured by the Ruminative Responses Scale) with polymorphisms of two...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26926881
DOI: 10.1038/tp.2016.19
PMCID: PMC4872445

Genes

MTHFR

Variants

rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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