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Article

Identification of actionable mutations in malignant pleural mesothelioma.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2014

Shukuya Takehito, Serizawa Masakuni, Watanabe Masaru, Akamatsu Hiroaki, Abe Masato, Imai Hisao, Tokito Takaaki, Ono Akira, Taira Tetsuhiko, Kenmotsu Hirotsugu, Naito Tateaki, Murakami Haruyasu, Takahashi Toshiaki, Endo Masahiro, Ohde Yasuhisa, Nakajima Takashi, Yamamoto Nobuyuki, Koh Yasuhiro

Abstract excerpt

BACKGROUND: Genetic alterations in malignant pleural mesothelioma (MPM) patients are not well-understood. PATIENTS AND METHODS: Surgical specimens and tumor biopsies from 42 patients with MPM were collected from 2003 to 2012. The samples were analyzed for mutations in EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN, and HER2 and amplifications in EGFR, MET, PIK3CA, FGFR1, and FGFR2. In addition, 21 patients'...

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Source

Identifiers

PMID: 25174276
DOI: 10.1016/j.lungcan.2014.08.004

Genes

EGFR
KRAS
AKT1
APC
BRAF
FGFR1
FGFR2
MET
NRAS
PTEN
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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