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CommonEGFR mutations conferring sensitivity to gefitinib in lung adenocarcinoma are not prevalent in human malignant mesothelioma

28 Jul 2005

Abstract excerpt

Dear Sir, Gefitinib (Iressa) is a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) that produces markedly favorable responses in a subset of patients with nonsmall cell lung cancer (NSCLC). Activating somatic mutations in the EGFR tyrosine-kinase domain (TKD) are strongly predictive of both clinical and in vitro sensitivity to gefitinib. To date, gefitinib-sensitizing EGFR mutations have...

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PMID: 16052537
DOI: 10.1002/ijc.21271

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