Article
BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model.
Neurobiology of disease - 1 Feb 2011
Shi SongTing, Hoogaars Willem M H, de Gorter David J J, van Heiningen Sandra H, Lin Herbert Y, Hong Charles C, Kemaladewi Dwi U, Aartsma-Rus Annemieke, ten Dijke Peter, 't Hoen Peter A C
Abstract excerpt
Duchenne Muscular Dystrophy (DMD) is an X-linked lethal muscle wasting disease characterized by muscle fiber degeneration and necrosis. The progressive pathology of DMD can be explained by an insufficient regenerative response resulting in fibrosis and adipose tissue formation. BMPs are known to inhibit myogenic differentiation and in a previous study we found an increased expression of a BMP family member BMP4...
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