Article
Inhibition of hepatitis B virus replication by MyD88 is mediated by nuclear factor-kappaB activation.
Biochimica et biophysica acta - 1 Oct 2007
Lin Shanshan, Wu Min, Xu Yang, Xiong Wei, Yi Zhigang, Zhang Xiaonan, Zhenghong Yuan
Abstract excerpt
In our previous paper, we reported that myeloid differential primary response protein (MyD88), a key adaptor in the signaling cascade of the innate immune response, inhibits hepatitis B virus (HBV) replication. The MyD88 activated nuclear factor-kappaB (NF-kappaB) signaling pathway and the intracellular upregulation of NF-kappaB signaling can induce an antiviral effect. Therefore, the association between the...
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