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Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice

26 Aug 2010

Abstract excerpt

High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established a model for HPV-associated HNSCC in which we treated transgenic mice expressing the papillomaviral oncoproteins with the chemical carcinogen 4-nitroquinoline-1-oxide (4-NQO). We found that the...

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PMID: 20797753
DOI: 10.1016/j.virol.2010.08.003

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