Article
Association of the interferon-gamma single nucleotide polymorphism +874(T/A) with response to immunosuppressive therapy in patients with severe aplastic anemia.
Blood cells, molecules & diseases - 15 Dec 2010
Chang Hong, Zeng Fan, Zhang Jia-You, Mu Xiao-Yan, Meng Wen-Tong, Ma Hong-Bing, Liu Ting
Abstract excerpt
The aim of this study was to investigate whether a single nucleotide polymorphism (SNP) +874T/A of interferon-gamma (IFN-γ) correlates with response to immunosuppressive therapy. Amplification refractory mutation system-polymerase chain reaction was used to amplify the polymorphic segments of the IFN-γ +874T/A gene in the samples obtained from 54 patients with aplastic anemia and 51 healthy adults. Further,...
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