Article
Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Sundelöf Johan, Sundström Johan, Hansson Oskar, Eriksdotter-Jönhagen Maria, Giedraitis Vilmantas, Larsson Anders, Degerman-Gunnarsson Malin, Ingelsson Martin, Minthon Lennart, Blennow Kaj, Kilander Lena, Basun Hans, Lannfelt Lars
Abstract excerpt
Cathepsin B is suggested to be involved in amyloid-β (Aβ) processing and Alzheimer's disease (AD). Studies of cathepsin B levels in plasma and cerebrospinal fluid (CSF) have not been previously performed. We examined cathepsin B levels in plasma and CSF samples in persons with AD, mild cognitive impairment (MCI), and healthy controls in order to test the hypothesis that cathepsin B levels can discriminate persons...
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