Article
Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Thambisetty Madhav, Tripaldi Romina, Riddoch-Contreras Joanna, Hye Abdul, An Yang, Campbell James, Sojkova Jitka, Kinsey Anna, Lynham Steven, Zhou Yun, Ferrucci Luigi, Wong Dean F, Lovestone Simon, Resnick Susan M
Abstract excerpt
Blood-based markers reflecting core pathological features of Alzheimer's disease (AD) in pre-symptomatic individuals are likely to accelerate the development of disease-modifying treatments. Our aim was to discover plasma proteins associated with brain amyloid-β (Aβ) burden in non-demented older individuals. We performed discovery-phase experiments using two dimensional gel electrophoresis (2DGE) and mass...
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