Article
Effects of mannose-binding lectin polymorphisms on irinotecan-induced febrile neutropenia.
The oncologist - 1 Jan 2010
van der Bol Jessica M, de Jong Floris A, van Schaik Ron H, Sparreboom Alex, van Fessem Marianne A, van de Geijn Fleur E, van Daele Paul L, Verweij Jaap, Sleijfer Stefan, Mathijssen Ron H
Abstract excerpt
OBJECTIVE: Mannose-binding lectin (MBL) is important in the innate immune response. MBL2 gene polymorphisms affect MBL expression, and genotypes yielding low MBL levels have been associated with an elevated risk for infections in hematological cancer patients undergoing chemotherapy. However, these reported associations are inconsistent, and data on patients with solid tumors are lacking. Here, we investigated...
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