Article
Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders.
Cancer science - 1 Apr 2009
Nakahashi Hirotaka, Tsukamoto Norifumi, Hashimoto Yoko, Koiso Hiromi, Yokohama Akihiko, Saitoh Takayuki, Uchiumi Hideki, Handa Hiroshi, Murakami Hirokazu, Nojima Yoshihisa, Karasawa Masamitsu
Abstract excerpt
The incidence of chronic lymphocytic leukemia is low in the Japanese population compared with populations in western countries, suggesting a role for genetic factors in the occurrence of this disease. We have previously shown that chronic lymphocytic leukemia in Japan rarely expresses the immunoglobulin heavy chain variable region (IGHV) 1-69 gene (1 out of 43 patients, 2.3%), which is a gene most commonly...
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