Article
Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q.
PloS one - 29 Sept 2010
Fenstad Mona H, Johnson Matthew P, Roten Linda T, Aas Per A, Forsmo Siri, Klepper Kjetil, East Christine E, Abraham Lawrence J, Blangero John, Brennecke Shaun P, Austgulen Rigmor, Moses Eric K
Abstract excerpt
BACKGROUND: Preeclampsia is a serious pregnancy complication, demonstrating a complex pattern of inheritance. The elucidation of genetic liability to preeclampsia remains a major challenge in obstetric medicine. We have adopted a positional cloning approach to identify maternal genetic components, with linkages previously demonstrated to chromosomes 2q, 5q and 13q in an Australian/New Zealand familial cohort. The...
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