Article
Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.
PloS one - 1 Jan 2012
Johnson Matthew P, Brennecke Shaun P, East Christine E, Göring Harald H H, Kent Jack W, Dyer Thomas D, Said Joanne M, Roten Linda T, Iversen Ann-Charlotte, Abraham Lawrence J, Heinonen Seppo, Kajantie Eero, Kere Juha, Kivinen Katja, Pouta Anneli, Laivuori Hannele, Austgulen Rigmor, Blangero John, Moses Eric K
Abstract excerpt
Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry using the Illumina OmniExpress-12 BeadChip to successfully genotype 648,175 SNPs in 538 preeclampsia cases and 540 normal pregnancy controls. Two SNP associations (rs7579169, p = 3.58×10(-7),...
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