Article
Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.
PLoS neglected tropical diseases - 28 Sept 2010
Depledge Daniel P, MacLean Lorna M, Hodgkinson Michael R, Smith Barbara A, Jackson Andrew P, Ma Saufung, Uliana Silvia R B, Smith Deborah F
Abstract excerpt
BACKGROUND: A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and can induce protective immune responses, the biological functions of these Leishmania-specific proteins...
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