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Article

Concepts and hypothesis: integrin cytoplasmic domain-associated protein-1 (ICAP-1) as a potential player in cerebral cavernous malformation.

Journal of neurology - 1 Jan 2013

Zheng Yiming, Qiu Juhui, Hu Jianjun, Wang Guixue

Abstract excerpt

Cerebral cavernous malformation (CCM) is a common vascular disease in central nervous system that frequently predisposes to stroke, seizure, and cerebral hemorrhage. CCM lesions are characterized by dilated and leaky intracranial capillaries composed of a thin layer of vascular endothelial cells with abnormal subendothelial extracellular matrix. Despite the understanding that genetic mutation of three CCM genes...

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Share to Hemangioma, Cavernous, Central Nervous System

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Source

Identifiers

PMID: 22711159
DOI: 10.1007/s00415-012-6567-6

Genes

CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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