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Article

Concepts and hypothesis: integrin cytoplasmic domain-associated protein-1 (ICAP-1) as a potential player in cerebral cavernous malformation.

Journal of neurology - 1 Jan 2013

Zheng Yiming, Qiu Juhui, Hu Jianjun, Wang Guixue

Abstract excerpt

Cerebral cavernous malformation (CCM) is a common vascular disease in central nervous system that frequently predisposes to stroke, seizure, and cerebral hemorrhage. CCM lesions are characterized by dilated and leaky intracranial capillaries composed of a thin layer of vascular endothelial cells...

Topics

Adaptor Proteins, Signal Transducing
Cardiovascular System
Hemangioma, Cavernous, Central Nervous System
Humans
Integrin beta1
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Models, Biological
Mutation
Neovascularization, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Subcellular Fractions

Source

Identifiers

PMID: 22711159
DOI: 10.1007/s00415-012-6567-6

Genes

CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22711159-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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