Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression.

doi:10.1073/pnas.1004654107

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Article

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2010

DeLisser Horace, Liu Yong, Desprez Pierre-Yves, Thor Ann, Briasouli Paraskevei, Handumrongkul Chakrapong, Wilfong Jonathon, Yount Garret, Nosrati Mehdi, Fong Sylvia, Shtivelman Emma, Fehrenbach Melane, Cao Gaoyuan, Moore Dan H, Nayak Shruti, Nyack Shruti, Liggitt Denny, Kashani-Sabet Mohammed, Debs Robert

Abstract excerpt

Most patients who die from cancer succumb to treatment-refractory advanced metastatic progression. Although the early stages of tumor metastasis result in the formation of clinically silent micrometastatic foci, its later stages primarily reflect the progressive, organ-destructive growth of already advanced metastases. Early-stage metastasis is regulated by multiple factors within tumor cells as well as by the...

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PMID: 20926749
DOI: 10.1073/pnas.1004654107
PMCID: PMC2973011

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