Article
HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.
Journal of virology - 1 Dec 2010
Mens Helene, Kearney Mary, Wiegand Ann, Shao Wei, Schønning Kristian, Gerstoft Jan, Obel Niels, Maldarelli Frank, Mellors John W, Benfield Thomas, Coffin John M
Abstract excerpt
Elucidating mechanisms leading to the natural control of HIV-1 infection is of great importance for vaccine design and for understanding viral pathogenesis. Rare HIV-1-infected individuals, termed HIV-1 controllers, have plasma HIV-1 RNA levels below the limit of detection by standard clinical assays (<50 to 75 copies/ml) without antiretroviral therapy. Although several recent studies have documented persistent...
Topics
- Adaptation, Physiological
- Adult
- Anti-HIV Agents
- Biological Evolution
- Case-Control Studies
- Control Groups
- DNA, Viral
- Female
- Genes, MHC Class I
- Genetic Variation