Article
Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller.
EBioMedicine - 1 Feb 2017
Walker-Sperling Victoria E, Pohlmeyer Christopher W, Veenhuis Rebecca T, May Megan, Luna Krystle A, Kirkpatrick Allison R, Laeyendecker Oliver, Cox Andrea L, Carrington Mary, Bailey Justin R, Arduino Roberto C, Blankson Joel N
Abstract excerpt
HIV-1 controllers are patients who control HIV-1 viral replication without antiretroviral therapy. Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood. We describe a patient who presented with acute HIV-1 infection and was found to have an HIV-1 RNA level of <100copies/mL. She did not have any known protective HLA...
Topics
- Alleles
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Female
- HIV Infections
- HIV-1
- HLA Antigens
- Host-Pathogen Interactions
- Humans