HIV Controllers: A Homogeneous Group of HIV-1--Infected Patients with Spontaneous Control of Viral Replication

Abstract excerpt

A small number of HIV-infected patients maintain high CD4+ T cell counts in the absence of antiretroviral therapy, despite a prolonged course of infection. These patients have been called long-term nonprogressors (LTNPs). The cause of the lack of disease progression in LTNPs is unclear, but long-term nonprogression seems to result from the interaction between factors linked to the virus (such as attenuation in...

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