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Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks

6 Oct 2010

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder involving variations in the transcriptome of many genes. AD does not affect all brain regions simultaneously. Identifying the differences among the affected regions may shed more light onto the disease progression. We developed a novel method involving the differential topology of gene coexpression networks to understand the...

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PMID: 20925940
DOI: 10.1186/1752-0509-4-136

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