Time to prophylactic surgery in BRCA1/2 carriers depends on psychological and other characteristics.

doi:10.1097/GIM.0b013e3181f48d1c

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Article

Time to prophylactic surgery in BRCA1/2 carriers depends on psychological and other characteristics.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Dec 2010

Julian-Reynier Claire, Bouhnik Anne-Déborah, Mouret-Fourme Emanuelle, Gauthier-Villars Marion, Berthet Pascaline, Lasset Christine, Fricker Jean-Pierre, Caron Olivier, Gesta Paul, Luporsi Elisabeth, Faivre Laurence, Longy Michel, Gladieff Laurence, Frenay Marc, Dreyfus Héléne, Sobol Hagay, Vennin Philippe, Nogués Catherine

Abstract excerpt

PURPOSE: To investigate the medical and psychosocial factors determining the time to prophylactic surgery of unaffected women carriers of a deleterious BRCA1/2 mutation. METHODS: Prospective study on a French national cohort of unaffected BRCA1/2 carriers (N = 244); multivariate Cox proportional hazard modeling. RESULTS: Median follow-up time was 2.33 years (range, 0.04-6.84 years). Time to surgery was shorter...

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PMID: 20921896
DOI: 10.1097/GIM.0b013e3181f48d1c

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BRCA1

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