Article
Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans.
Cell - 22 Oct 1993
Goodwin E B, Okkema P G, Evans T C, Kimble J
Abstract excerpt
C. elegans hermaphrodites make sperm and then oocytes in an otherwise female animal. Gain-of-function mutations in the sex-determining gene tra-2 (tra-2(gf)) transform hermaphrodites into females (spermless hermaphrodites). The tra-2(gf) mutations map to a perfect direct repeat in the 3' untranslated region; each repeat is called a direct repeat element (DRE). Three experiments demonstrate that DREs repress tra-2...
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