Article
A bioluminescent microbial biosensor for in vitro pretreatment assessment of cytarabine efficacy in leukemia.
Clinical chemistry - 1 Dec 2010
Alloush Habib M, Anderson Elizabeth, Martin Ashley D, Ruddock Mark W, Angell Johanna E, Hill Phil J, Mehta Priyanka, Smith M Ann, Smith J Graham, Salisbury Vyv C
Abstract excerpt
BACKGROUND: The nucleoside analog cytarabine (Ara-C [cytosine arabinoside]) is the key agent for treating acute myeloid leukemia (AML); however, up to 30% of patients fail to respond to treatment. Screening of patient blood samples to determine drug response before commencement of treatment is needed. This project aimed to construct and evaluate a self-bioluminescent reporter strain of Escherichia coli for use as...
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