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Article

SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.

BMC cancer - 4 Oct 2010

Komlósi Viktor, Hitre Erika, Pap Eva, Adleff Vilmos, Réti Andrea, Székely Eva, Bíró Anna, Rudnai Péter, Schoket Bernadette, Müller Judit, Tóth Béla, Ottó Szabolcs, Kásler Miklós, Kralovánszky Judit, Budai Barna

Abstract excerpt

BACKGROUND: Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS: The SHMT1 and MTHFR genotypes were determined by real-time PCR and PCR-RFLP, respectively in 476 patients with rectal, 479...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glycine Hydroxymethyltransferase

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Restriction Fragment Length

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Source

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Identifiers

PMID: 20920350
DOI: 10.1186/1471-2407-10-525
PMCID: PMC2958941

Genes

SHMT1
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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