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Article

Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.

Pharmacogenetics and genomics - 1 Jan 2012

Budai Barna, Komlósi Viktor, Adleff Vilmos, Pap Éva, Réti Andrea, Nagy Tünde, Kralovánszky Judit, Láng István, Hitre Erika

Abstract excerpt

The impact of thymidylate synthase (TYMS), methylenetetrahydrofolate reductase (MTHFR), and serine hydroxymethyltransferase 1 (SHMT1) gene polymorphisms and that of dihydropyrimidine dehydrogenase (DPD) enzyme activity, serum total homocysteine level, and estimated serum creatinine clearance on first-line 5-fluorouracil, leucovorin, irinotecan, and bevacizumab (FOLFIRI+bevacizumab) regimen efficacy in metastatic...

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Source

Identifiers

PMID: 22044939
DOI: 10.1097/FPC.0b013e32834d8376

Genes

SHMT1
TYMS
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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