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Article

C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.

The Journal of biological chemistry - 2 May 2014

Nakano Naoko, Maeyama Kota, Sakata Nobuo, Itoh Fumiko, Akatsu Ryosuke, Nakata Miki, Katsu Yuki, Ikeno Souichi, Togawa Yoko, Vo Nguyen Thanh Thao, Watanabe Yukihide, Kato Mitsuyasu, Itoh Susumu

Abstract excerpt

Transforming growth factor (TGF)-β signaling is deliberately regulated at multiple steps in its pathway from the extracellular microenvironment to the nucleus. However, how TGF-β signaling is activated or attenuated is not fully understood. We recently identified transmembrane prostate androgen-induced RNA (TMEPAI), which is involved in a negative feedback loop of TGF-β signaling. When we searched for a family...

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PMID: 24627487
DOI: 10.1074/jbc.M114.558981
PMCID: PMC4007458

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