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Article

Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype-phenotype relationships.

European journal of endocrinology - 1 May 2010

Brioude Frédéric, Bouligand Jérôme, Trabado Séverine, Francou Bruno, Salenave Sylvie, Kamenicky Peter, Brailly-Tabard Sylvie, Chanson Philippe, Guiochon-Mantel Anne, Young Jacques

Abstract excerpt

Congenital hypogonadotropic hypogonadism (CHH) results from abnormal gonadotropin secretion, and it is characterized by impaired pubertal development. CHH is caused by defective GNRH release, or by a gonadotrope cell dysfunction in the pituitary. Identification of genetic abnormalities related to CHH has provided major insights into the pathways critical for the development, maturation, and function of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20207726
DOI: 10.1530/EJE-10-0083

Genes

GNRH1
GNRHR
TAC3
TACR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype-phenotype relationships.PMID 20207726Read ↗

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