Evaluation of PvuII and XbaI polymorphisms in the estrogen receptor alpha gene (ESR1) in relation to menstrual cycle timing and reproductive parameters in post-menopausal women.

doi:10.1016/j.maturitas.2010.08.006

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Article

Evaluation of PvuII and XbaI polymorphisms in the estrogen receptor alpha gene (ESR1) in relation to menstrual cycle timing and reproductive parameters in post-menopausal women.

Maturitas - 1 Dec 2010

Silva Ian Victor, Rezende Lucas Cunha Dias, Lanes Silvania Pereira, Souza Letícia Soncini, Madeira Klesia Pirola, Cerri Murilo Fanchiotti, Paes Marcela Ferreira, Daltoé Renata Dalmaschio, Chambô-Filho Antônio, Guimarães Marco César Cunegundes, Graceli Jones Bernardes, Rangel Leticia Batista Azevedo

Abstract excerpt

OBJECTIVE: To evaluate the association of -397T>C and -351A>G single nucleotide polymorphisms (SNPs) - also called PvuII and XbaI, respectively - located on estrogen receptor alpha (ERS1) gene with age at menarche, menopause onset, fertility and miscarriage in a population of post-menopausal women. STUDY DESIGN: Cross-sectional study with 273 healthy, high miscegenated, post-menopausal women (mean age of 63.1±9.7...

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PMID: 20884142
DOI: 10.1016/j.maturitas.2010.08.006

Genes

ESR1

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