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Article

Risk of premature ovarian failure is associated to the PvuII polymorphism at estrogen receptor gene ESR1.

Journal of assisted reproduction and genetics - 1 Dec 2012

Cordts Emerson Barchi, Santos Aline Amaro, Peluso Carla, Bianco Bianca, Barbosa Caio Parente, Christofolini Denise Maria

Abstract excerpt

PURPOSE: Estrogen plays an important role in the human reproductive system and it action is mediated mainly by two specific receptors: α (ERα) and β (ERβ). There were described polymorphic variants in ESR1 and ESR2 genes and studies showed controversial results regarding their association with premature ovarian failure. We aimed to determine the prevalence of ESR1 and ESR2 polymorphisms in Brazilian patients and...

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Source

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Identifiers

PMID: 23150099
DOI: 10.1007/s10815-012-9884-x
PMCID: PMC3528877

Genes

ESR1
ESR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Risk of premature ovarian failure is associated to the PvuII polymorphism at estrogen receptor gene ESR1.PMID 23150099Read ↗

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The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging.Semantic proximity Read ↗

Evaluation of PvuII and XbaI polymorphisms in the estrogen receptor alpha gene (ESR1) in relation to menstrual cycle timing and reproductive parameters in post-menopausal women.Semantic proximity Read ↗

A Study on the Role of Estrogen Receptor Gene Polymorphisms in Female Infertility.Semantic proximity Read ↗

Estrogen receptor alpha gene polymorphisms are associated with idiopathic premature ovarian failure.Semantic proximity Read ↗

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