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Association of polymorphisms in estrogen receptors (ESR1 and ESR2) with male infertility: a meta-analysis and systematic review.

Journal of assisted reproduction and genetics - 1 May 2014

Ge Yu-Zheng, Xu Lu-Wei, Jia Rui-Peng, Xu Zheng, Li Wen-Cheng, Wu Ran, Liao Sheng, Gao Fei, Tan Si-Jia, Song Qun, Xin Hui

Abstract excerpt

PURPOSE: Estrogens play an important role in male reproduction via interacting with estrogen receptors (ERs), whose expression can be regulated by the polymorphisms in different regions of ESR1 and ESR2 genes. However, results from published studies on the association between four well-characterized polymorphisms (PvuII, XbaI, RsaI, and AluI) in the gene of ERs (ESR1 and ESR2) and male infertility risk are...

Topics

Asian People
Deoxyribonucleases, Type II Site-Specific
Estrogen Receptor alpha
Estrogen Receptor beta
Genetic Predisposition to Disease
Humans
Infertility, Male
Male
Odds Ratio
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24647635
DOI: 10.1007/s10815-014-0212-5
PMCID: PMC4016379

Genes

ESR2
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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