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Article

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4.

Developmental biology - 1 Dec 2010

Fujimori Sayumi, Novak Hermann, Weissenböck Martina, Jussila Maria, Gonçalves Alexandre, Zeller Rolf, Galloway Jenna, Thesleff Irma, Hartmann Christine

Abstract excerpt

Loss- and gain-of function approaches modulating canonical Wnt/β-catenin activity have established a role for the Wnt/β-catenin pathway during tooth development. Here we show that Wnt/β-catenin signaling is required in the dental mesenchyme for normal incisor development, as locally restricted genetic inactivation of β-catenin results in a splitting of the incisor placode, giving rise to two incisors. Molecularly...

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Source

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Identifiers

PMID: 20883686
DOI: 10.1016/j.ydbio.2010.09.009
PMCID: PMC2997430

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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