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Article

Peptide inhibitors of flavivirus entry derived from the E protein stem.

Journal of virology - 1 Dec 2010

Schmidt Aaron G, Yang Priscilla L, Harrison Stephen C

Abstract excerpt

Peptides derived from the "stem" of dengue virus (DV) type 2 (DV2) envelope (E) protein inhibit DV2 infectivity, targeting a late-stage fusion intermediate. We show here that stem peptides from all DV serotypes cross-inhibit DV1 to DV4 but that corresponding peptides derived from related flaviviruses do not. This failure to inhibit infection is not due to poor interaction with the E protein but rather to loss of...

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Identifiers

PMID: 20881042
DOI: 10.1128/JVI.01440-10
PMCID: PMC3004314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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