Article
Dissecting the functional domains of a nonenveloped virus membrane penetration peptide.
Journal of virology - 1 Jul 2009
Banerjee Manidipa, Khayat Reza, Walukiewicz Hanna E, Odegard Amy L, Schneemann Anette, Johnson John E
Abstract excerpt
Recent studies have established that several nonenveloped viruses utilize virus-encoded lytic peptides for host membrane disruption. We investigated this mechanism with the "gamma" peptide of the insect virus Flock House virus (FHV). We demonstrate that the C terminus of gamma is essential for membrane disruption in vitro and the rescue of immature virus infectivity in vivo, and the amphipathic N terminus of...
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